Article
Molecular diagnostics for pharmacogenomic testing of fluoropyrimidine based-therapy: costs, methods and applications.
Clinical chemistry and laboratory medicine - 1 Jul 2011
Di Francia Raffaele, Berretta Massimiliano, Catapano Oriana, Canzoniero Lorella M T, Formisano Luigi
Abstract excerpt
Abstract Genetic testing of drug response represents an important goal for targeted therapy. In particular, 5-fluorouracil (5-FU) is the backbone of several chemotherapic protocols for treatment of solid tumors. Unfortunately, in some patients, 5-FU is toxic and causes gastrointestinal and hematologic lesions leading to the suspension of therapy. Some adverse drug responses can be predicted by pharmacogenomics....
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