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Methylcap-Seq Reveals Novel DNA Methylation Markers for the Diagnosis and Recurrence Prediction of Bladder Cancer in a Chinese Population

17 Apr 2012

Abstract excerpt

PURPOSE: There is a need to supplement or supplant the conventional diagnostic tools, namely, cystoscopy and B-type ultrasound, for bladder cancer (BC). We aimed to identify novel DNA methylation markers for BC through genome-wide profiling of BC cell lines and subsequent methylation-specific PCR (MSP) screening of clinical urine samples. EXPERIMENTAL DESIGN: The methyl-DNA binding domain (MBD) capture technique,...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 22529986
DOI: 10.1371/journal.pone.0035175

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