Article
Estimating the genetic variance of major depressive disorder due to all single nucleotide polymorphisms.
Biological psychiatry - 15 Oct 2012
Lubke Gitta H, Hottenga Jouke Jan, Walters Raymond, Laurin Charles, de Geus Eco J C, Willemsen Gonneke, Smit Jan H, Middeldorp Christel M, Penninx Brenda W J H, Vink Jacqueline M, Boomsma Dorret I
Abstract excerpt
Genome-wide association studies of psychiatric disorders have been criticized for their lack of explaining a considerable proportion of the heritability established in twin and family studies. Genome-wide association studies of major depressive disorder in particular have so far been unsuccessful in detecting genome-wide significant single nucleotide polymorphisms (SNPs). Using two recently proposed methods...
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