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Article

ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2.

The Journal of biological chemistry - 15 Nov 2002

He Guocheng, Gupta Sarita, Yi Ming, Michaely Peter, Hobbs Helen H, Cohen Jonathan C

Abstract excerpt

Mutations in the phosphotyrosine binding domain protein ARH cause autosomal recessive hypercholesterolemia, a disorder caused by defective internalization of low density lipoprotein receptors (LDLR) in the liver. To examine the function of ARH, we used pull-down experiments to test for interactions between ARH, the LDLR, and proteins involved in clathrin-mediated endocytosis. The phosphotyrosine binding domain of...

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Share to Adaptor Protein Complex 2
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12221107
DOI: 10.1074/jbc.M208539200

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2.PMID 12221107Read ↗

The modular adaptor protein autosomal recessive hypercholesterolemia (ARH) promotes low density lipoprotein receptor clustering into clathrin-coated pits.Semantic proximity Read ↗

The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinerySemantic proximity Read ↗

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ARH cooperates with AP-1B in the exocytosis of LDLR in polarized epithelial cells.Semantic proximity Read ↗

Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein.Semantic proximity Read ↗

Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail.Semantic proximity Read ↗

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Genetics, clinical phenotype, and molecular cell biology of autosomal recessive hypercholesterolemia.Semantic proximity Read ↗

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Disruption of autosomal recessive hypercholesterolemia gene shows different phenotype in vitro and in vivo.Semantic proximity Read ↗

Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1Semantic proximity Read ↗

Premature senescence in cells from patients with autosomal recessive hypercholesterolemia (ARH): evidence for a role for ARH in mitosis.Semantic proximity Read ↗

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