Article
Complex control of GABA(A) receptor subunit mRNA expression: variation, covariation, and genetic regulation.
PloS one - 1 Jan 2012
Mulligan Megan K, Wang Xusheng, Adler Adrienne L, Mozhui Khyobeni, Lu Lu, Williams Robert W
Abstract excerpt
GABA type-A receptors are essential for fast inhibitory neurotransmission and are critical in brain function. Surprisingly, expression of receptor subunits is highly variable among individuals, but the cause and impact of this fluctuation remains unknown. We have studied sources of variation for all 19 receptor subunits using massive expression data sets collected across multiple brain regions and platforms in...
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