Article
[Clinical aspects of familial ovarian cancer - current status and issues in Japan].
Gan to kagaku ryoho. Cancer & chemotherapy - 1 Apr 2012
Sekine Masayuki, Yoshihara Kosuke, Tanaka Kenichi
Abstract excerpt
Familial ovarian cancer occurs as part of two genetically distinct syndromes: hereditary breast and ovarian cancer (HBOC) and hereditary nonpolyposis colorectal cancer (HNPCC). HBOC caused by inherited mutations of BRCA1/2 and HNPCC caused by mismatch-repair genes are considered responsible for a...
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