Article
Apoptosis resistance and PKC signaling: distinguishing features of high and low metastatic cells.
Neoplasia (New York, N.Y.) - 1 Mar 2012
Hong Sung-Hyeok, Ren Ling, Mendoza Arnulfo, Eleswarapu Ananth, Khanna Chand
Abstract excerpt
The complexity of the process of metastasis is widely recognized. We report herein on a recurrent feature of high compared to low metastatic cells that is linked to their ability to survive early after their arrival at secondary sites. Using novel fluorescent-based imaging strategies that assess tumor cell interaction with the lung microenvironment, we have determined that most high and low metastatic cells can...
Topics
- Animals
- Apoptosis
- Cell Line, Tumor
- Cell Proliferation
- Female
- Humans
- Lung Neoplasms
- Mice
- Mice, Inbred BALB C
- Neoplasms
- Phenotype
- Protein Kinase C
- Protein Kinase Inhibitors
- Proto-Oncogene Proteins c-akt
- Signal Transduction