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Article

Human colonic epithelial cells detect and respond to C5a via apically expressed C5aR through the ERK pathway.

American journal of physiology. Cell physiology - 15 Jun 2012

Cao Qi, McIsaac Shayla M, Stadnyk Andrew W

Abstract excerpt

Intestinal epithelial cells (IECs) exhibit numerous adaptations to maintain barrier function as well as play sentinel roles by expressing receptors for microbial products and antimicrobial peptides. The complement system is another important innate sensing and defense mechanism of the host against bacteria and increasing evidence shows that complement plays a role in colitis. The split component C5a is a potent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22496247
DOI: 10.1152/ajpcell.00213.2011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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