Article
Nutraceutical-mediated restoration of wild-type levels of IKBKAP-encoded IKAP protein in familial dysautonomia-derived cells.
Molecular nutrition & food research - 1 Apr 2012
Anderson Sylvia L, Liu Bo, Qiu Jinsong, Sturm Andrea J, Schwartz Jamie A, Peters Austin J, Sullivan Kerry A, Rubin Berish Y
Abstract excerpt
SCOPE: The reported ability to modulate the production of the wild-type transcript in cells bearing the splice-altering familial dysautonomia (FD)-causing mutation in the IKBKAP gene prompted an evaluation of the impact of commonly consumed nutraceuticals on the splicing of this transcript. METHODS AND RESULTS: Screening efforts revealed the ability of the isoflavones, genistein, and daidzein, to impact splicing...
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