Article
Tocotrienols induce IKBKAP expression: a possible therapy for familial dysautonomia.
Biochemical and biophysical research communications - 20 Jun 2003
Anderson Sylvia L, Qiu Jinsong, Rubin Berish Y
Abstract excerpt
Familial dysautonomia (FD), a neurodegenerative genetic disorder primarily affecting individuals of Ashkenazi Jewish descent, is caused by mutations in the IKBKAP gene which encodes the IkappaB kinase complex-associated protein (IKAP). The more common or major mutation causes aberrant splicing, resulting in a truncated form of IKAP. Tissues from individuals homozygous for the major mutation contain both mutant...
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