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Article

Similar clinical and neuroimaging features in monozygotic twin pair with mutation in progranulin.

Neurology - 17 Apr 2012

McDade E, Boeve B F, Burrus T M, Boot B P, Kantarci K, Fields J, Lowe V J, Peller P, Knopman D, Baker M, Finch N, Rademakers R, Petersen R

Abstract excerpt

OBJECTIVE: To report the phenotypic characterization of monozygotic twins with mutations encoding progranulin (PGRN). METHODS: We studied a twin pair with an exon 4 gene deletion in the PGRN gene. Both twins had clinical and neuropsychological examinations as well as structural MRI and fluorodeoxyglucose PET (FDG-PET) scans. PGRN gene sequencing was performed followed by progranulin ELISA in plasma. RESULTS: Both...

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Identifiers

PMID: 22491866
DOI: 10.1212/WNL.0b013e318251594c
PMCID: PMC3324318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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