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Article

Bayesian method to predict individual SNP genotypes from gene expression data.

Nature genetics - 1 May 2012

Schadt Eric E, Woo Sangsoon, Hao Ke

Abstract excerpt

RNA profiling can be used to capture the expression patterns of many genes that are associated with expression quantitative trait loci (eQTLs). Employing published putative cis eQTLs, we developed a Bayesian approach to predict SNP genotypes that is based only on RNA expression data. We show that predicted genotypes can accurately and uniquely identify individuals in large populations. When inferring genotypes...

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PMID: 22484626
DOI: 10.1038/ng.2248

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