Article
ISL1 common variant rs1017 is not associated with susceptibility to congenital heart disease in a Chinese population.
Genetic testing and molecular biomarkers - 1 Jul 2012
Xue Lei, Wang Xiaowei, Xu Jing, Xu Xiaohan, Liu Xiang, Hu Zhibin, Shen Hongbing, Chen Yijiang
Abstract excerpt
BACKGROUND: ISL1, as a member of the LIM homeodomain transcription factor family, is expressed in a distinct population of undifferentiated cardiac progenitors and plays a pivotal role in cardiogenesis. Lacking ISL1 expression results in growth arrest or displays profound defects in heart development, including atria, ventricle, and the inflow and outflow tracts, which constitute a major form of congenital heart...
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