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Article

A systematic review of familial Alzheimer's disease: Differences in presentation of clinical features among three mutated genes and potential ethnic differences.

Journal of the Formosan Medical Association = Taiwan yi zhi - 1 Feb 2016

Shea Yat-Fung, Chu Leung-Wing, Chan Angel On-Kei, Ha Joyce, Li Yan, Song You-Qiang

Abstract excerpt

There are great diversities of clinical phenotypes among the various familial Alzheimer's disease (FAD) families. We aimed to systematically review all the previously reported cases of FAD and to perform comparisons between Asian and white patients. In this regard, we collected individual-level data from 658 pedigrees. We found that patients with presenilin 1 (PSEN1) mutations had the earliest age of onset (AOO;...

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Source

Identifiers

PMID: 26337232
DOI: 10.1016/j.jfma.2015.08.004

Genes

APP
PSEN1
PSEN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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