Maternal high-fat diet programs for metabolic disturbances in offspring despite leptin sensitivity.

Abstract excerpt

A fatty diet during pregnancy in mouse dams causes metabolic abnormalities (similar to metabolic syndrome in humans) in the rodents' offspring. We tested the hypothesis that the offspring of dams fed a high-fat diet during pregnancy and lactation develop metabolic abnormalities and leptin resistance. Pregnant C57BL/6 mice (n = 20) were fed either standard chow (SC; 19% fat) or a high-fat diet (HF; 49% fat). After...

Topics

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• Adiposity
• Blood Glucose
• Diet, High-Fat
• Dietary Fats
• Insulin Resistance