Article
The type II secretion system and its ubiquitous lipoprotein substrate, SslE, are required for biofilm formation and virulence of enteropathogenic Escherichia coli.
Infection and immunity - 1 Jun 2012
Baldi Deborah L, Higginson Ellen E, Hocking Dianna M, Praszkier Judyta, Cavaliere Rosalia, James Catherine E, Bennett-Wood Vicki, Azzopardi Kristy I, Turnbull Lynne, Lithgow Trevor, Robins-Browne Roy M, Whitchurch Cynthia B, Tauschek Marija
Abstract excerpt
Enteropathogenic Escherichia coli (EPEC) is a major cause of diarrhea in infants in developing countries. We have identified a functional type II secretion system (T2SS) in EPEC that is homologous to the pathway responsible for the secretion of heat-labile enterotoxin by enterotoxigenic E. coli. The wild-type EPEC T2SS was able to secrete a heat-labile enterotoxin reporter, but an isogenic T2SS mutant could not....
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