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Article

Characterization of β-lactamase and porin mutants of Enterobacteriaceae selected with ceftaroline + avibactam (NXL104).

The Journal of antimicrobial chemotherapy - 1 Jun 2012

Livermore David M, Mushtaq Shazad, Barker Kevin, Hope Russell, Warner Marina, Woodford Neil

Abstract excerpt

OBJECTIVES: Ceftaroline + avibactam (NXL104) is a novel inhibitor combination active against Enterobacteriaceae with class A and C β-lactamases. We investigated its risk of mutational resistance. METHODS: Single- and multi-step mutants were sought and characterized from Enterobacteriaceae with ex...

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Source

Identifiers

PMID: 22441578
DOI: 10.1093/jac/dks079

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22441578-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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