Article
MFGE8 does not influence chorio-retinal homeostasis or choroidal neovascularization in vivo.
PloS one - 1 Jan 2012
Raoul William, Poupel Lucie, Tregouet David-Alexandre, Lavalette Sophie, Camelo Serge, Keller Nicole, Krumeich Sophie, Calippe Bertrand, Guillonneau Xavier, Behar-Cohen Francine, Cohen Salomon-Yves, Baatz Holger, Combadière Christophe, Théry Clotilde, Sennlaub Florian
Abstract excerpt
PURPOSE: Milk fat globule-epidermal growth factor-factor VIII (MFGE8) is necessary for diurnal outer segment phagocytosis and promotes VEGF-dependent neovascularization. The prevalence of two single nucleotide polymorphisms (SNP) in MFGE8 was studied in two exsudative or "wet" Age-related Macular Degeneration (AMD) groups and two corresponding control groups. We studied the effect of MFGE8 deficiency on retinal...
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