Article
Possible involvement of the E-cadherin gene in genetic susceptibility to endometriosis.
Human reproduction (Oxford, England) - 1 Jun 2012
Yoshida Kunihiko, Yoshihara Kosuke, Adachi Sosuke, Haino Kazufumi, Nishino Koji, Yamaguchi Masayuki, Nishikawa Nobumichi, Kashima Katsunori, Yahata Tetsuro, Masuzaki Hideaki, Katabuchi Hidetaka, Ikuma Kenichiro, Suginami Hiroshi, Tanaka Kenichi
Abstract excerpt
BACKGROUND: Endometriotic cells display invasive characteristics, despite their benign histological appearance. Recently, the epithelial-mesenchymal transition, in which epithelial cells acquire mesenchymal and migratory properties, has attracted attention as a mechanism of tumor invasion. We aimed to investigate the association between endometriosis and polymorphisms of the E-cadherin gene, a central player in...
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