Article
The hygiene hypothesis does not apply to atopic eczema in childhood.
Chemical immunology and allergy - 1 Jan 2012
Cramer Claudia, Link Elke, Koletzko Sibylle, Lehmann Irina, Heinrich Joachim, Wichmann H-Erich, Bauer Carl-P, V Berg Andrea, Berdel Dietrich, Herbarth Olf, Schaaf Beate, Borte Michael, Behrendt Heidrun, Krämer Ursula
Abstract excerpt
There is evidence that environmental factors are important for the development of eczema. Different mechanisms have been discussed in the literature, the best known of which is the hygiene hypothesis. However, epidemiological data give reason for questioning this hypothesis with regard to childhood eczema. We present results from two German birth cohort studies (LISAplus and GINIplus) concerning regional...
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