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Article

End-recovery QTc: a useful metric for assessing genetic variants of unknown significance in long-QT syndrome.

Journal of cardiovascular electrophysiology - 1 Jun 2012

Obeyesekere Manoj N, Sy Raymond W, Klein George J, Gula Lorne J, Modi Simon, Conacher Susan, Leong-Sit Peter, Skanes Allan C, Yee Raymond, Krahn Andrew D

Abstract excerpt

INTRODUCTION: Genetic variants represent benign single-nucleotide polymorphisms, disease causing mutations or variants of unknown significance (VUS). Resting, exercise, and recovery QTc intervals have been utilized to detect long-QT syndrome (LQTS) mutations. We sought to provide clinical data that may assist in classifying the presented VUS as disease causing/benign and to determine whether resting and/or...

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Source

Identifiers

PMID: 22429796
DOI: 10.1111/j.1540-8167.2011.02265.x

Genes

SCD
KCNH2
KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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