Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Breast cancers with compromised DNA repair exhibit selective sensitivity to elesclomol.

DNA repair - 1 May 2012

Alli Elizabeth, Ford James M

Abstract excerpt

The basal-like subtype of breast cancers, including those that contain germline mutations in BRCA1, tend to be triple-negative (i.e. lack expression of estrogen and progesterone receptors and lack overexpression/amplification of the HER2/neu oncogene), which renders them relatively insensitive to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Breast Neoplasms
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Genes, BRCA1

Share to Hydrazines

Share to Reactive Oxygen Species

Share to Receptor, ErbB-2

Source

Identifiers

PMID: 22425348
DOI: 10.1016/j.dnarep.2012.02.003

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-22425348-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Breast cancers with compromised DNA repair exhibit selective sensitivity to elesclomol.PMID 22425348Read ↗

Potential Phytochemicals for Prevention of Familial Breast Cancer with BRCA Mutations.Semantic proximity Read ↗

Elesclomol induces cancer cell apoptosis through oxidative stressSemantic proximity Read ↗

Endocrine therapy resistance: new insights.Semantic proximity Read ↗

Enterolactone: A novel radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosisSemantic proximity Read ↗

Loss of ARID1A expression leads to sensitivity to ROS-inducing agent elesclomol in gynecologic cancer cells.Semantic proximity Read ↗

The DNA damage repair landscape in Black women with breast cancerSemantic proximity Read ↗

Oxidative DNA base damage in MCF-10A breast epithelial cells at clinically achievable concentrations of doxorubicinSemantic proximity Read ↗

Is There a Role for Base Excision Repair in Estrogen/Estrogen Receptor-Driven Breast Cancers?Semantic proximity Read ↗

BRCA 1 and 2 mutation status: the elephant in the room during oncofertility counseling for young breast cancer patients.Semantic proximity Read ↗

Targeting XRCC1 Deficiency in Breast Cancer for Personalized TherapySemantic proximity Read ↗

Chemoprevention of breast cancer for women at high risk.Semantic proximity Read ↗

Parabens Promote Pro-Tumorigenic Effects in Luminal Breast Cancer Cell Lines with Diverse Genetic AncestrySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.