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Article

Long-Term Evaluation of a Phase 1 Study of AADC Gene Therapy for Parkinson's Disease

16 Mar 2012

Abstract excerpt

We report the results of a long-term follow-up of subjects in a phase 1 study of AAV2-hAADC (adeno-associated virus type 2–human aromatic L-amino acid decarboxylase) gene therapy for the treatment of Parkinson's disease (PD). Ten patients with moderately advanced PD received bilateral putaminal infusions of either a low or a high dose of AAV2-hAADC vector. An annual positron emission tomography (PET) imaging with...

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PMID: 22424171
DOI: 10.1089/hum.2011.220

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