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Article

DNA Methylation Is Associated with Altered Gene Expression in AMD

13 Mar 2012

Abstract excerpt

PURPOSE: Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. Evidence suggests oxidative stress plays a role in the disease. To assess the potential contribution of epigenetic regulation of antioxidant genes relevant to AMD pathogenesis, we evaluated DNA methylation, a tissue-specific genetic modulation that affects gene expression. METHODS: Using the Infinium...

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PMID: 22410570
DOI: 10.1167/iovs.11-8449

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