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Article

Mechanical loading induces the expression of a Pol I regulon at the onset of skeletal muscle hypertrophy

8 Mar 2012

Abstract excerpt

The main goal of the present study was to investigate the regulation of ribosomal DNA (rDNA) gene transcription at the onset of skeletal muscle hypertrophy. Mice were subjected to functional overload of the plantaris by bilateral removal of the synergist muscles. Mechanical loading resulted in muscle hypertrophy with an increase in rRNA content. rDNA transcription, as determined by 45S pre-rRNA abundance,...

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PMID: 22403788
DOI: 10.1152/ajpcell.00460.2011

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