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Article

Nucleosomes suppress spontaneous mutations base-specifically in eukaryotes.

Science (New York, N.Y.) - 9 Mar 2012

Chen Xiaoshu, Chen Zhidong, Chen Han, Su Zhijian, Yang Jianfeng, Lin Fangqin, Shi Suhua, He Xionglei

Abstract excerpt

It is unknown how the composition and structure of DNA within the cell affect spontaneous mutations. Theory suggests that in eukaryotic genomes, nucleosomal DNA undergoes fewer C→T mutations because of suppressed cytosine hydrolytic deamination relative to nucleosome-depleted DNA. Comparative genomic analyses and a mutation accumulation experiment showed that nucleosome occupancy nearly eliminated cytosine...

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Identifiers

PMID: 22403392
DOI: 10.1126/science.1217580

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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