Article
Identification of specific vascular endothelial growth factor susceptible and protective haplotypes associated with recurrent spontaneous miscarriages.
Human reproduction (Oxford, England) - 1 May 2012
Magdoud K, Dendana M, Herbepin V, Hizem S, Ben Jazia K, Messaoudi S, Almawi W Y, Touraine R, Mahjoub T
Abstract excerpt
BACKGROUND: We investigated the association of vascular endothelial growth factor (VEGF) gene polymorphism with recurrent spontaneous miscarriage (RSM). METHODS: VEGF -2578C/A, -1154G/A, -634G/C, +936C/T single nucleotide polymorphisms (SNPs) were assessed in 304 RSM patients, and 371 age-and body mass index-matched control subjects using real-time PCR. RESULTS: Higher minor allele frequency of -1154G/A (P <...
Topics
- Abortion, Habitual
- Adult
- Case-Control Studies
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Polymorphism, Single Nucleotide
- Real-Time Polymerase Chain Reaction