Article
Positive association between STAT4 polymorphisms and polymyositis/dermatomyositis in a Japanese population.
Annals of the rheumatic diseases - 1 Oct 2012
Sugiura Tomoko, Kawaguchi Yasushi, Goto Kanako, Hayashi Yukiko, Tsuburaya Rie, Furuya Takefumi, Gono Takahisa, Nishino Ichizo, Yamanaka Hisashi
Abstract excerpt
OBJECTIVES: To investigate associations between signal transducer and activator of transcription 4 (STAT4), one of the most commonly acknowledged genes for the risk of multiple autoimmune diseases, with susceptibility to adult-onset polymyositis/dermatomyositis among Japanese individuals. METHODS: A single nucleotide polymorphism of STAT4, rs7574865, was genotyped using TaqMan assay in 1143 Japanese individuals....
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