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Article

Regulation of karyopherin α1 and nuclear import by mammalian target of rapamycin.

The Journal of biological chemistry - 27 Apr 2012

Fielhaber Jill A, Tan Jason, Joung Kwang-Bo, Attias Ortal, Huegel Stefanie, Bader Michael, Roux Philippe P, Kristof Arnold S

Abstract excerpt

Under conditions of reduced mitogen or nutritional substrate levels, the serine/threonine kinase target of rapamycin can augment the nuclear content of distinct transcription factors and promote the induction of stress response genes. In its latent (i.e., unphosphorylated) form, the transcription factor STAT1 regulates a subset of genes involved in immune modulation and apoptosis. Based on previous work...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22399302
DOI: 10.1074/jbc.M111.246785
PMCID: PMC3340278

Genes

STAT1
KPNA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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