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Article

Intracellular distribution, assembly and effect of disease-associated connexin 31 mutants in HeLa cells.

Acta biochimica et biophysica Sinica - 1 Aug 2005

He Li-Qiang, Liu Yu, Cai Fang, Tan Zhi-Ping, Pan Qian, Liang De-Sheng, Long Zhi-Gao, Wu Ling-Qian, Huang Liang-Qun, Dai He-Ping, Xia Kun, Xia Jia-Hui, Zhang Zhuo-Hua

Abstract excerpt

Mutations in connexin 31 (Cx31) are associated with erythrokeratodermia variabilis (EKV), hearing impairment and peripheral neuropathy; however, the pathological mechanism of Cx31 mutants remains unknown. This study analyzed 11 disease-associated Cx31 variants and one non-disease-associated Cx31 variant and compared their intracellular distribution and assembly in HeLa cells and their effect on these cells. The...

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PMID: 16077902
DOI: 10.1111/j.1745-7270.2005.00080.x

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