Article
Description and molecular modeling of a novel human leukocyte antigen allele: A*32:22.
Human immunology - 1 May 2012
Mantovani Martina, Crivello Pietro, Frison Sara, Longhi Elena, Fleischhauer Katharina, Scalamogna Mario, Poli Francesca
Abstract excerpt
We describe here the sequence and the molecular modeling of a new variant of HLA-A*32 allele officially named A*32:22. This novel allele has been detected in an Italian cord blood sample by sequence-based typing (SBT). The mutation (CAT →CGT), which has occurred at codon 151, at nucleotide position 524, implies an amino acidic change from Histidine to Arginine. Residue 151 is located on top of the molecule inside...
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