Article
Molecular aspects of a novel HLA-A*02 allele (A*0297): the first HLA class I allele mutated at codon 232.
Tissue antigens - 1 Apr 2007
Garino E, Miertus J, Berrino M, Bertinetto F, Caropreso P, Gay V, Mazzola G, Tondat F, Frecer V, Miertus S, Amoroso A
Abstract excerpt
We describe a new HLA-A*02 allele, identified in a cord blood unit and in her mother. Nucleotide sequence analysis showed the presence of a new HLA-A*02 allele identical to HLA-A*02010101 except for a non-synonymous nucleotide exchange in exon 4 modifying codon 232 from GAG (Glu) to GAC (Asp). No other human leucocyte antigen class I allele sequenced so far shows this triplet at codon 232. The amino acid exchange...
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