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Article

Cyclophosphamide and 4-hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis.

British journal of clinical pharmacology - 1 Sept 2012

Joy Melanie S, La Mary, Wang Jinzhao, Bridges Arlene S, Hu Yichun, Hogan Susan L, Frye Reginald F, Blaisdell Joyce, Goldstein Joyce A, Dooley Mary Anne, Brouwer Kim L R, Falk Ronald J

Abstract excerpt

AIMS: Cyclophosphamide, the precursor to the active 4-hydroxycyclophosphamide, is used in active glomerulonephritis despite limited pharmacokinetics data. The pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide were evaluated. The influence of laboratory and pharmacogenomic covaria...

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Share to Chromatography, Liquid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2B6

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Share to Oxidoreductases, N-Demethylating

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Source

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Identifiers

PMID: 22380717
DOI: 10.1111/j.1365-2125.2012.04223.x
PMCID: PMC3477346

Genes

ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22380717-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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