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Article

Detection of <i>bcr</i> - <i>abl</i> Fusion in Chronic Myelogeneous Leukemia by in Situ Hybridization

26 Oct 1990

Abstract excerpt

Chronic myelogeneous leukemia (CML) is genetically characterized by fusion of the bcr and abl genes on chromosomes 22 and 9, respectively. In most cases, the fusion involves a reciprocal translocation t(9;22)(q34;q11), which produces the cytogenetically distinctive Philadelphia chromosome (Ph1). Fusion can be detected by Southern (DNA) analysis or by in vitro amplification of the messenger RNA from the fusion...

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PMID: 2237408
DOI: 10.1126/science.2237408

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Detection of <i>bcr</i> - <i>abl</i> Fusion in Chronic Myelogeneous Leukemia by in Situ HybridizationPMID 2237408Read ↗

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