Cardiac amyloidosis: report of a patient heterozygous for the transthyretin isoleucine 122 variant.

doi:10.1111/j.1365-3083.1990.tb02928.x

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Article

Cardiac amyloidosis: report of a patient heterozygous for the transthyretin isoleucine 122 variant.

Scandinavian journal of immunology - 1 Oct 1990

Saraiva M J, Sherman W, Marboe C, Figueira A, Costa P, de Freitas A F, Gawinowicz M A

Abstract excerpt

Amyloid fibril material was extracted from autopsy material of a patient who died from progressive cardiac failure at age 64. He had enlarged heart on routine X-ray at age 47 and the first symptoms of cardiac failure at age 62. Fractionation of the fibril material resolved peptide fragments immun...

Topics

Amino Acid Sequence
Amyloidosis
Cardiomyopathies
Chromatography, High Pressure Liquid
Heterozygote
Humans
Male
Middle Aged
Molecular Sequence Data
Peptide Mapping
Phenotype
Prealbumin

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