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Article

Synthesis and biological evaluation of pyrimidine-based dual inhibitors of human epidermal growth factor receptor 1 (HER-1) and HER-2 tyrosine kinases.

Journal of medicinal chemistry - 22 Mar 2012

Cha Mi Young, Lee Kwang-Ok, Kang Seok-Jong, Jung Young Hee, Song Ji Yeon, Choi Kyung Jin, Byun Joo Yun, Lee Han-Jae, Lee Gwan Sun, Park Seung Bum, Kim Maeng Sup

Abstract excerpt

A novel series of N(4)-(3-chlorophenyl)-5-(oxazol-2-yl)pyrimidine-4,6-diamines were synthesized and evaluated as dual inhibitors of HER-1/HER-2 tyrosine kinases. In contrast to the currently approved HER-2-targeted agent (lapatinib, 1), our irreversible HER-1/HER-2 inhibitors have the potential t...

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PMID: 22372864
DOI: 10.1021/jm201758g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22372864-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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