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Article

Term myometrium is characterized by increased activating epigenetic modifications at the progesterone receptor-A promoter

27 Feb 2012

Abstract excerpt

Term human myometrial expression of progesterone receptor (PR)-A is increased relative to PR-B, and as PR-A is a repressor of progesterone action mediated through PR-B, this increase may mediate the withdrawal of progesterone action and precipitate the onset of labour. PR-A and PR-B expression is regulated by two separate promoters of the PR gene. We hypothesized that epigenetic histone modifications at the two...

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Share to Estrogen and related hormone effects
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PMID: 22369759
DOI: 10.1093/molehr/gas012

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