Article
Unrecognized sequence homologies may confound genome-wide association studies.
Nucleic acids research - 1 Jun 2012
Galichon Pierre, Mesnard Laurent, Hertig Alexandre, Stengel Bénédicte, Rondeau Eric
Abstract excerpt
Genome-wide association studies (GWAS) have become a preferred method to identify new genetic susceptibility loci. This technique aims to understanding the molecular etiology of common diseases, but in many cases, it has led to the identification of loci with no obvious biological relevance. Herein, we show that previously unrecognized sequence homologies have caused single-nucleotide polymorphism (SNP)...
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