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Article

Down-regulation of the transcription factor snail in the placentas of patients with preeclampsia and in a rat model of preeclampsia

1 Jan 2012

Abstract excerpt

BACKGROUND: Placental malfunction in preeclampsia is believed to be a consequence of aberrant differentiation of trophoblast lineages and changes in utero-placental oxygenation. The transcription factor Snail, a master regulator molecule of epithelial-mesenchymal transition in embryonic development and in cancer, is shown to be involved in trophoblast differentiation as well. Moreover, Snail can be controlled by...

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Share to Physiological and biochemical adaptations
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PMID: 22360878
DOI: 10.1186/1477-7827-10-15

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