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Article

Transcription regulates telomere dynamics in human cancer cells

22 Feb 2012

Abstract excerpt

Telomeres are nucleoprotein structures capping the physical ends of linear eukaryotic chromosomes. Although largely heterochromatic, telomeres are transcribed into telomeric repeat-containing RNA (TERRA) molecules by RNA polymerase II. The functions associated with telomere transcription and TERRA remain ill defined. Here we show that the transcriptional activity of human telomeres directly regulates their...

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Identifiers

PMID: 22357912
DOI: 10.1261/rna.029587.111

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