Genetic variation and linkage disequilibrium in Bacillus anthracis.

doi:10.1038/srep00169

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Article

Genetic variation and linkage disequilibrium in Bacillus anthracis.

Scientific reports - 1 Jan 2011

Zwick Michael E, Thomason Maureen Kiley, Chen Peter E, Johnson Henry R, Sozhamannan Shanmuga, Mateczun Alfred, Read Timothy D

Abstract excerpt

We performed whole-genome amplification followed by hybridization of custom-designed resequencing arrays to resequence 303 kb of genomic sequence from a worldwide panel of 39 Bacillus anthracis strains. We used an efficient algorithm contained within a custom software program, UniqueMER, to identify and mask repetitive sequences on the resequencing array to reduce false-positive identification of genetic...

Topics

Alleles
Animals
Bacillus anthracis
Bacterial Typing Techniques
DNA, Bacterial
Evolution, Molecular
Genetic Variation
Genome, Bacterial
Humans
Linkage Disequilibrium
Oligonucleotide Array Sequence Analysis
Phylogeny
Polymorphism, Single Nucleotide
Recombination, Genetic

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Identifiers

PMID: 22355684
DOI: 10.1038/srep00169
PMCID: PMC3240990

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