Article
Biallelic inactivation of the SDHC gene in renal carcinoma associated with paraganglioma syndrome type 3.
Endocrine-related cancer - 1 Jun 2012
Malinoc Angelica, Sullivan Maren, Wiech Thorsten, Schmid Kurt Werner, Jilg Cordula, Straeter Joern, Deger Serdar, Hoffmann Michael M, Bosse Alexander, Rasp Gerd, Eng Charis, Neumann Hartmut P H
Abstract excerpt
The etiology and pathogenesis of renal cell carcinoma (RCC) are only partially understood. Key findings in hereditary RCC, which may be site specific or a component of a syndrome, have contributed to our current understanding. Important heritable syndromes of RCC are those associated with pheochromocytoma, especially von Hippel-Lindau disease (VHL) associated with germline VHL mutations, and pheochromocytoma and...
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