Article
Mixed effects modeling of proliferation rates in cell-based models: consequence for pharmacogenomics and cancer.
PLoS genetics - 1 Feb 2012
Im Hae Kyung, Gamazon Eric R, Stark Amy L, Huang R Stephanie, Cox Nancy J, Dolan M Eileen
Abstract excerpt
The International HapMap project has made publicly available extensive genotypic data on a number of lymphoblastoid cell lines (LCLs). Building on this resource, many research groups have generated a large amount of phenotypic data on these cell lines to facilitate genetic studies of disease risk or drug response. However, one problem that may reduce the usefulness of these resources is the biological noise...
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