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Article

A Novel Immediate-Early Response Gene of Endothelium Is Induced by Cytokines and Encodes a Secreted Protein

1 Nov 1990

Abstract excerpt

We have previously described the cloning of a group of novel cellular immediate-early response genes whose expression in human umbilical vein endothelial cells is induced by tumor necrosis factor alpha in the presence of cycloheximide. These genes are likely to participate in mediating the response of the vascular endothelium to proinflammatory cytokines. In this study, we further characterized one of these novel...

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PMID: 2233719
DOI: 10.1128/mcb.10.11.5830-5838.1990

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