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Article

Early Growth Response‐1, an Integrative Sensor in Cardiovascular and Inflammatory Disease

10 Nov 2021

Abstract excerpt

Early growth response-1 (Egr-1) is a master regulator and transcriptional sensor in vascular dysfunction and disease. This article reviews recent developments in our understanding of the regulatory roles this zinc finger protein and product of an immediate-early gene plays in a range of cardiovascular and inflammatory disorders. Egr-1 can amplify pathologic signals from the extracellular environment by serving as...

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PMID: 34755520
DOI: 10.1161/jaha.121.023539

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