Cloning of a novel tumor necrosis factor-α-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro

Abstract excerpt

TNF is a proinflammatory cytokine that has pleiotropic effects on cells and tissues, mediated in large part by alterations in target tissue gene expression. We have used the technique of differential hybridization to identify several primary response genes induced by TNF in human umbilical vein endothelial (HUVE) cells, a cell type that is profoundly activated by cytokine treatment. One of these cDNA, designated...