Article
Neisseria gonorrhoeae virulence factor NG1686 is a bifunctional M23B family metallopeptidase that influences resistance to hydrogen peroxide and colony morphology.
The Journal of biological chemistry - 30 Mar 2012
Stohl Elizabeth A, Chan Yolande A, Hackett Kathleen T, Kohler Petra L, Dillard Joseph P, Seifert H Steven
Abstract excerpt
Symptomatic gonococcal infection, caused exclusively by the human-specific pathogen Neisseria gonorrhoeae (the gonococcus), is characterized by the influx of polymorphonuclear leukocytes (PMNs) to the site of infection. Although PMNs possess a potent antimicrobial arsenal comprising both oxidative and non-oxidative killing mechanisms, gonococci survive this interaction, suggesting that the gonococcus has evolved...
Topics
- Anti-Bacterial Agents
- Carboxypeptidases
- Catalytic Domain
- Conserved Sequence
- Drug Resistance, Bacterial
- Endopeptidases
- Escherichia coli
- Hydrogen Peroxide
- Metalloproteases
- Mutation
- Neisseria gonorrhoeae
- Neutrophils