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Article

Antiviral activity of TMC435 monotherapy in patients infected with HCV genotypes 2-6: TMC435-C202, a phase IIa, open-label study.

Journal of hepatology - 1 Jun 2012

Moreno Christophe, Berg Thomas, Tanwandee Tawesak, Thongsawat Satawat, Van Vlierberghe Hans, Zeuzem Stefan, Lenz Oliver, Peeters Monika, Sekar Vanitha, De Smedt Goedele

Abstract excerpt

BACKGROUND & AIMS: TMC435 is an investigational, once-daily, oral NS3/4A protease inhibitor currently in phase III development for the treatment of hepatitis C virus (HCV) infection. Phase I and II studies in patients infected with HCV genotype 1 have demonstrated that TMC435 is generally well tolerated, has a pharmacokinetic profile that supports once daily dosing, and demonstrates potent antiviral activity....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22326470
DOI: 10.1016/j.jhep.2011.12.033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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