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Article

Efficacy, safety and pharmacokinetics of simeprevir and TMC647055/ritonavir with or without ribavirin and JNJ-56914845 in HCV genotype 1 infection.

BMC gastroenterology - 10 Feb 2017

Bourgeois Stefan, Van Vlierberghe Hans, Moreno Christophe, Orlent Hans, Nevens Frederik, Arastéh Keikawus, Horsmans Yves, Schattenberg Jörn M, Buggisch Peter, Francque Sven, Vijgen Leen, Kakuda Thomas N, Hoeben Eva, Luo Donghan, Vandebosch An, Jacquemyn Bert, Van Remoortere Pieter, Verloes René

Abstract excerpt

BACKGROUND: A Phase 2a, open-label study (NCT01724086) was conducted to assess the efficacy and safety of a once-daily, 2-direct-acting-antiviral-agent (2-DAA) combination of simeprevir + TMC647055/ritonavir ± ribavirin and of the 3-DAA combination of simeprevir + TMC647055/ritonavir + JNJ-56914845 in chronic hepatitis C virus genotype (GT)1-infected treatment-naïve and prior-relapse patients. METHODS: The study...

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Identifiers

PMID: 28187751
DOI: 10.1186/s12876-017-0580-2
PMCID: PMC5303260

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