Article
Inter-homolog crossing-over and synapsis in Arabidopsis meiosis are dependent on the chromosome axis protein AtASY3.
PLoS genetics - 1 Feb 2012
Ferdous Maheen, Higgins James D, Osman Kim, Lambing Christophe, Roitinger Elisabeth, Mechtler Karl, Armstrong Susan J, Perry Ruth, Pradillo Mónica, Cuñado Nieves, Franklin F Chris H
Abstract excerpt
In this study we have analysed AtASY3, a coiled-coil domain protein that is required for normal meiosis in Arabidopsis. Analysis of an Atasy3-1 mutant reveals that loss of the protein compromises chromosome axis formation and results in reduced numbers of meiotic crossovers (COs). Although the frequency of DNA double-strand breaks (DSBs) appears moderately reduced in Atasy3-1, the main recombination defect is a...
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